Deep-brain recordings showed that Mounjaro and Zepbound briefly shut down the craving circuits linked to food noise in a patient with severe obesity. Her obsessive thoughts about food disappeared as the medication quieted the nucleus accumbens, the brain’s reward hub.

Researchers revealed that the microbial metabolite TMA can directly block the immune protein IRAK4, reducing inflammation and improving insulin sensitivity. The molecule counteracts damage caused by high-fat diets and even protects mice from sepsis. Since IRAK4 is a known drug target, this pathway could inspire new diabetes therapies. The study highlights how gut microbes and nutrition can work together to support metabolic health.

A large Mayo Clinic study shows that current guidelines fail to detect nearly 90% of people with familial hypercholesterolemia, a common inherited cause of dangerously high cholesterol. Many affected individuals already had early heart disease but never met testing criteria. Routine DNA screening could dramatically expand detection and prevention. The research underscores the need for genomics-driven healthcare.

Scientists found that kale’s prized nutrients are hard for the body to absorb unless they’re eaten with oil. Cooking doesn’t improve absorption, but adding oil-based dressings—or even more advanced nanoemulsion sauces—does. These combinations dramatically increase access to kale’s carotenoids. The research could inspire new, healthier dressings designed to supercharge everyday vegetables.

Using less ipilimumab appears to make melanoma immunotherapy both safer and more effective, with dramatically better response and survival outcomes. The findings suggest that reducing side effects may be the key to maximizing the benefits of these powerful treatments.