FGF19 triggers the brain to burn more energy and activate fat-burning cells, offering a potential new path for obesity treatments. The hormone enhances thermogenesis and reduces inflammation, but only when the sympathetic nervous system is active. Researchers uncovered how cold exposure increases receptor expression for FGF19 in the hypothalamus, hinting at an evolutionary role in temperature regulation. Ongoing work aims to discover how to boost natural production of this powerful metabolic hormone.

Scientists uncovered a surprising four-layer structure hidden inside the hippocampal CA1 region, one of the brain’s major centers for memory, navigation, and emotion. Using advanced RNA imaging techniques, the team mapped more than 330,000 genetic signals from tens of thousands of neurons, revealing crisp, shifting bands of cell types that run along the length of the hippocampus. This layered organization may help explain why different parts of CA1 support different behaviors and why certain neurons break down more easily in disorders such as Alzheimer’s disease and epilepsy.

A next-generation drug tested in yeast was found to extend lifespan and slow aging by influencing a major growth-control pathway. Researchers also uncovered an unexpected role for agmatinases, enzymes that help keep this pathway in balance. Diet and gut microbes may affect aging more than expected because they produce the metabolites involved.

Regular consumption of polyphenol-rich foods like tea, coffee, berries, nuts, and whole grains may significantly support long-term heart health. A decade-long study of more than 3,100 adults found that those who consistently ate polyphenol-packed diets had healthier blood pressure and cholesterol levels, as well as lower predicted cardiovascular risk.

A large study found that people with impaired kidneys tend to have higher Alzheimer’s biomarkers, yet they don’t face a higher overall risk of dementia. For those who already have elevated biomarkers, kidney problems may speed up when symptoms appear. The findings show that kidney health can change how Alzheimer’s blood tests are read. Doctors may need to consider both organs to get a clearer picture.