People who naturally stay up late may be putting their hearts under added strain as they age. A large study tracking more than 300,000 adults found that middle-aged and older night owls had poorer overall heart health and a higher risk of heart attack and stroke than those who were active earlier in the day, with the effect especially pronounced in women. Much of this elevated risk appeared to stem from lifestyle factors common among evening types, including smoking and inadequate sleep.

Men start developing heart disease earlier than women, with risks rising faster beginning around age 35, according to long-term research. The difference is driven mainly by coronary heart disease, not stroke or heart failure. Traditional risk factors explain only part of the gap. The findings suggest earlier screening could help catch problems before serious damage occurs.

A new drug developed by Australian researchers has shown promising results in reducing sepsis in a Phase II clinical trial involving 180 patients. The carbohydrate-based treatment works by calming a dangerous immune reaction that can cause organ failure. With no specific anti-sepsis therapy currently available, the findings mark a major step forward. Researchers now aim to move into Phase III trials.

Researchers have discovered how pancreatic cancer reprograms its surroundings to spread quickly and stealthily. By using a protein called periostin, the tumor remodels nearby tissue and invades nerves, which helps cancer cells travel and form metastases. This process also creates a tough, fibrous barrier that makes treatments less effective. Targeting periostin could help stop this invasion before it starts.

A fast-aging fish is giving scientists a rare, accelerated look at how kidneys grow old—and how a common drug may slow that process down. Researchers found that SGLT2 inhibitors, widely used to treat diabetes and heart disease, preserved kidney structure, blood vessels, and energy production as the fish aged, while also calming inflammation. The results help explain why these drugs protect kidneys and hearts so reliably in people, even beyond blood sugar control.